The 5 Best Wrinkle Products on the Market in 2025

Adrienne Stewart, MD

Adrienne Stewart, MD

+ Specialist Bio

Adrienne Stewart, MD, is a board-certified dermatologist at Aesthetic Surgery and Dermatology of Cherry Creek in Denver, Colorado. She's passionate about helping patients feel comfortable in their skin. She has more than 29 years of medical and cosmetic dermatology experience and stays abreast with the latest advances in technologies and proven treatments.

Dr. Stewart has over 25 years of experience completing injections. She taught cosmetic dermatology injection techniques at the University of Colorado in Denver for years and regularly takes continuing cadaver classes on injection techniques and theory.

Dr. Stewart attends yearly classes, studying the facial muscles and how to best combat common signs of aging.

Dr. Stewart is passionate about giving back to her community and teaching next-generation dermatologists. She enjoys improving her patients' lives by improving their skin health, appearance, and self-confidence. Dr. Stewart develops strong, long-lasting interpersonal relationships with her patients.

She earned her bachelor's and medical degrees at Tulane University in New Orleans, Louisiana. She also completed an internship and residency in dermatology at Tulane Charity Hospital, where she was a chief resident.

Dr. Stewart is a clinical assistant professor at the University of Colorado and a clinical instructor for internal medicine residents at St. Joseph Hospital in Denver.

She is also a national trainer in cosmetic injectables and a fellow of the American Academy of Dermatology. Dr. Stewart is a member of numerous professional organizations, including the Women's Dermatologic Society, Colorado Medical Society, Colorado Dermatologic Society, Denver Medical Society, and the American Society of Cosmetic Dermatology and Aesthetic Surgery.

She has been featured on numerous media programs and in publications, including WB, CBC, ABC, NBC, and Fox News, as well as Elle Magazine, Vogue Magazine, Bloom, and 5280 Magazine, which awarded her Top Dermatologist. She also regularly presents at prestigious medical seminars.

In her free time, Dr. Stewart loves gardening, spending time with her husband, and cheering on the Nuggets, Avalanche, and Broncos.

Dr. Stewart welcomes new and existing patients to Aesthetic Surgery and Dermatology of Cherry Creek and looks forward to maximizing their skin's health.

In my three decades of clinical experience as a board-certified dermatologist, I've witnessed firsthand the evolution of skincare products aimed at combating the signs of aging.

In 2025, the market is saturated with wrinkle creams, each claiming to be the ultimate solution for youthful skin. However, not all products deliver on their promises. It's essential to discern which formulations are backed by science and which are merely marketing hype.

In this comprehensive review, I present the top five wrinkle creams available in 2025, with a critical eye on their formulations, benefits, and potential drawbacks.

Notably, SoluRetinol stands out as the premier choice, offering a unique blend of ingredients that set it apart from the competition.

#2 Skinbetter Science AlphaRet Overnight Cream

Skinbetter Science AlphaRet Overnight Cream

Skinbetter Science AlphaRet Overnight Cream

Overall Rating (4.3)
★★★★☆

Skinbetter Science's AlphaRet Overnight Cream is renowned for its unique combination of retinoid and alpha hydroxy acid (AHA), designed to deliver the benefits of retinol with minimal irritation.

It's particularly suitable for individuals with sensitive skin who are new to retinoid products. And while AlphaRet is a solid choice for those with sensitive skin, it may not provide the comprehensive anti-aging benefits found in more robust formulations like SoluRetinol.

Pros

  • Gentle formulation combines retinoid with lactic acid for exfoliation without significant irritation
  • Hydrating ingredients that support skin hydration and barrier function
  • Dermatologist recommended for its efficacy and tolerability

Cons

  • Higher price point may be cost-prohibitive for some consumers
  • Users may experience gradual improvements rather than rapid changes

#3 RoC Retinol Correxion Deep Wrinkle Night Cream

RoC Retinol Correxion Deep Wrinkle Night Cream

RoC Retinol Correxion Deep Wrinkle Night Cream

Overall Rating (4.1)
★★★★☆

RoC's Retinol Correxion Deep Wrinkle Night Cream is a long-standing favorite in the drugstore category, offering retinol-based wrinkle treatment at an accessible price point.

All in all, RoC's offering is a commendable entry-level retinol cream.

However, for those seeking a more comprehensive approach to anti-aging, products with broader ingredient profiles may be more effective.

Pros

  • Affordable pricing gives users retinol treatment without a hefty price tag
  • Easily found in most drugstores and online retailers
  • Many users report noticeable improvements in skin texture and fine lines

Cons

  • May cause dryness or sensitivity, especially for first-time retinol users
  • Basic formulation lacks additional anti-aging ingredients that could enhance efficacy

#4 Dr. Dennis Gross Advanced Retinol + Ferulic Intense Wrinkle Cream

Dr. Dennis Gross Advanced Retinol + Ferulic Intense Wrinkle Cream

Dr. Dennis Gross Advanced Retinol + Ferulic Intense Wrinkle Cream

Overall Rating (3.9)
★★★☆☆

This cream combines retinol with ferulic acid and other botanicals to provide anti-aging benefits while aiming to reduce potential irritation.

It's marketed as a suitable option for those with sensitive skin.

While this cream offers a gentler approach to retinol treatment, its efficacy may not match that of more potent formulations like SoluRetinol.

Pros

  • Botanical ingredients incorporate plant-based components to soothe the skin
  • Hydrating formula maintains skin moisture levels
  • Developed by a reputable skincare professional

Cons

  • Complex routine may require additional products for optimal results
  • Some users may not experience significant improvements

#5 Clinique Smart Clinical Repair Wrinkle Correcting Cream

Clinique Smart Clinical Repair Wrinkle Correcting Cream

Clinique Smart Clinical Repair Wrinkle Correcting Cream

Overall Rating (3.8)
★★★☆☆

Clinique's wrinkle correcting cream is designed to be a gentle option for those new to anti-aging products.

It focuses on hydration and skin barrier support. This cream serves as a good starting point for those new to anti-aging skincare.

However, for more pronounced results, transitioning to a more robust product like SoluRetinol is advisable.

Pros

  • Gentle and suitable for sensitive skin types
  • Hydrating formula helps maintain skin moisture
  • Fragrance-free to reduce the risk of irritation

Cons

  • Limited potency may not provide significant wrinkle reduction
  • Basic formulation lacks advanced anti-aging ingredients